Bronchiectasis exacerbations, or flare-ups, have a major impact on those with bronchiectasis and leads to poor quality of life, a decline in lung function and increased healthcare costs. The Team has previously described how exacerbations should be defined in children, this study will be a validation study using a different cohort to produce a more robust definition for future clinical use.


To examine and validate a diagnostic criterion for acute bronchiectasis exacerbation in a new cohort.


Using bloods previously stored from completed the completed RCTs BEST 1 & 2 and prospectively collected clinical data, the previously defined criteria will be applied to this new cohort and evaluated. The full dataset will also be used to examine acute exacerbation phenotypes.

Lead investigator
Dr Vikas Goyal
Chief investigator
Professor Shyamali Dharmage
Project type
Project period