Understanding macrophage dysfuntion in protacted bacterial bronchitis and bronchiectasis

This project builds on our recent findings about certain type of immune cells known as macrophages. Our research found that macrophages in the lungs of children with protracted bacterial bronchitis appear functionally paralysed relative to macrophages from healthy children, with reduced capacity to respond to bacterial challenge. The aim of this study is to develop a molecular signature of that macrophage dysfunction that can be applied to stored lung samples from Indigenous children with chronic suppurative lung disease and bronchiectasis. We can then use this molecular signature to determine if macrophage dysfunction predicts clinical outcomes in children with protracted bacterial bronchitis which may help us predict those children who will have the worst outcomes.

Main publications:

Pediatr Pulmonol. 2018;53(5):575-582  https://www.ncbi.nlm.nih.gov/pubmed/29575797

 2018;4(1) pii: 00130-2017  https://www.ncbi.nlm.nih.gov/pubmed/29594175

 2017;3(4) pii: 00025-2017  https://www.ncbi.nlm.nih.gov/pubmed/29204435

 

Lead investigator
Dr Alice Chen
Chief investigator
Professor John Upham
Project period