First Nations children have one of the world’s highest published rates of hospitalised pneumonia and chronic lung disease including bronchiectasis (BE). Children from developing countries are also at a similar...
Acute lower respiratory infections (ALRIs), including pneumonia, are one of the major causes of childhood mortality and morbidity worldwide, and early childhood infection is associated with future chronic lung disease...
Acute respiratory infections are the most common cause of hospitalisation for First Nation children in the Northern Territory. Several years ago, the Team showed that First Nation infants with lower...
Acute lower respiratory infections are a leading cause of recurrent hospitalisation, and early and repeated infections in young children increase the risk of chronic lung conditions such as bronchiectasis. Therefore...
Children with neurological impairment are at high-risk of lower respiratory tract infections, leading to recurrent hospitalisations and a burden on the family and healthcare system. To prevent these lower respiratory...
Bronchiectasis is a major cause of chronic lung disease and its prevalence among Northern territory First Nations children is very high (one in every 63-68 children). Current therapies include regular...
Cough is one of the most common symptoms in those seeking primary healthcare and chronic cough (>4 weeks) causes considerate morbidity and reduced quality of life. Substantial work conducted by...
Our current understanding of the complex pathways leading to bronchiectasis are poorly understood. Mathematical modelling and machine learning are powerful techniques that can define and identify new pathways and endotypes...
The early and accurate detection of bronchiectasis is paramount to initiate treatment and to reverse early disease. The diagnosis of bronchiectasis is based upon the pathognomonic radiological finding of an...
Currently there is very little knowledge or understanding of childhood bronchiectasis phenotypes and endotypes, however this knowledge is required to better understand the risk factors for bronchiectasis development and prognosis...
It is important to understand the bacterial composition (microbiota) within the airways to then understand the effect it has on disease initiation, recurrence and progression. This can then also help...
Bronchiectasis exacerbations, or flare-ups, have a major impact on those with bronchiectasis and leads to poor quality of life, a decline in lung function and increased healthcare costs. The Team...
Repeat hospital admissions occur with bronchiectasis and data from Europe, USA and New Zealand suggests that bronchiectasis results in high hospital costs. In Australia, bronchiectasis has only recently been recognised...
Antibiotics are central in the treatment of bronchiectasis. However, bronchiectasis is a heterogenous disease and therefore it is not surprising that studies previously completed by the CRE (BEST-1, BEST-2 and...
A number of RCTs, including a previous CRE study, have shown that long-term azithromycin reduces the rate of bronchiectasis exacerbations in both children and adults. However, these studies have varied...
It is well recognised that high-quality, routine clinical care is important for good health outcomes. For bronchiectasis, this requires early recognition and treatment of cough which is one of the...
The European Lung Foundation (ELF) undertook two surveys to help shape the future of childhood bronchiectasis, as part of the European Respiratory Society taskforce to develop a "Clinical practice guidelines...
We recently received funding from The European Respiratory Society to work with the European Lung Foundation (ELF) develop a robust and consensus definition of bronchiectasis flare-ups (exacerbations) for use in...
Protracted bacterial bronchitis (PBB) is a common cause of chronic wet cough in children. Many children with PBB experience flare-ups associated with recurrent chest infections. Repeated flare-ups increase the risk...
Primary Ciliary Dyskinesia (PCD) is a rare, progressive, inherited disease that affects the motile cilia of cells. It is incurable and frequently complicated by the development of bronchiectasis. Although earlier...
